Unsubstituted polyaromatic dications exhibit a significant influence on the activity of topoisomerase I, as shown by plasmid relaxation assays and molecular modeling studies. Moreover, these compounds inhibit the growth of selected human tumor cell lines.
Diazoniapolycyclic ions inhibit the activity of topoisomerase I and the growth of certain tumor cell lines.
BASILI, SERENA;BASSO, GIUSEPPE;FACCIO, ANITA;MORO, STEFANO;VIOLA, GIAMPIETRO
2008
Abstract
Unsubstituted polyaromatic dications exhibit a significant influence on the activity of topoisomerase I, as shown by plasmid relaxation assays and molecular modeling studies. Moreover, these compounds inhibit the growth of selected human tumor cell lines.
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