Sfoglia per Autore
Human neural progenitor cell models to study the antiviral effects and neuroprotective potential of approved and investigational human cytomegalovirus inhibitors
2024 Trevisan, M.; Pianezzola, A.; Onorati, M.; Apolloni, L.; Pistello, M.; Arav-Boger, R.; Palu, G.; Mercorelli, B.; Loregian, A.
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability
2023 Gao, S.; Song, L.; Sylvester, K.; Mercorelli, B.; Loregian, A.; Toth, K.; Weisse, R. H.; Useini, A.; Strater, N.; Yang, M.; Ye, B.; Tollefson, A. E.; Muller, C. E.; Liu, X.; Zhan, P.
A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells
2023 Bertagnin, C.; Messa, L.; Pavan, M.; Celegato, M.; Sturlese, M.; Mercorelli, B.; Moro, S.; Loregian, A.
Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo
2023 Celegato, M.; Sturlese, M.; Costa, V. V.; Trevisan, M.; Dias, A. S. L.; Passos, I. B. S.; Queiroz-Junior, C. M.; Messa, L.; Favaro, A.; Moro, S.; Teixeira, M. M.; Loregian, A.; Mercorelli, B.
Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization
2022 Mercorelli, Beatrice; Desantis, Jenny; Celegato, Marta; Bazzacco, Alessandro; Siragusa, Lydia; Benedetti, Paolo; Eleuteri, Michela; Croci, Federico; Cruciani, Gabriele; Goracci, Laura; Loregian, Arianna
Targeted disruption of e6/p53 binding exerts broad activity and synergism with paclitaxel and topotecan against hpv-transformed cancer cells
2022 Celegato, M.; Messa, L.; Bertagnin, C.; Mercorelli, B.; Loregian, A.
The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs
2021 Mercorelli, B.; Celegato, M.; Luganini, A.; Gribaudo, G.; Lepesheva, G. I.; Loregian, A.
Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication
2021 Ghassabian, Hanieh; Falchi, F; Timmoneri, M; Mercorelli, B; Loregian, A; Palu, G; Alvisi, G
Indomethacin-based PROTACs as pan-coronavirus antiviral agents
2021 Desantis, J.; Mercorelli, B.; Celegato, M.; Croci, F.; Bazzacco, A.; Baroni, M.; Siragusa, L.; Cruciani, G.; Loregian, A.; Goracci, L.
The dimeric form of hpv16 e6 is crucial to drive yap/taz upregulation through the targeting of hscrib
2021 Messa, L.; Celegato, M.; Bertagnin, C.; Mercorelli, B.; Alvisi, G.; Banks, L.; Palu, G.; Loregian, A.
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
2020 Celegato, M.; Messa, L.; Goracci, L.; Mercorelli, B.; Bertagnin, C.; Spyrakis, F.; Suarez, I.; Cousido-Siah, A.; Trave, G.; Banks, L.; Cruciani, G.; Palu, G.; Loregian, A.
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication
2020 Mercorelli, Beatrice; Luganini, Anna; Celegato, Marta; Palu', Giorgio; Gribaudo, Giorgio; Lepesheva, Galina I.; Loregian, Arianna
The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity
2019 Luganini, Anna; Mercorelli, Beatrice; Messa, Lorenzo; Palù, Giorgio; Gribaudo, Giorgio; Loregian, Arianna
Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance
2019 Nannetti, Giulio; Massari, Serena; Mercorelli, Beatrice; Bertagnin, Chiara; Desantis, Jenny; Palù, Giorgio; Tabarrini, Oriana; Loregian, Arianna
Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts"
2019 Mercorelli, Beatrice; Luganini, Anna; Palù, Giorgio; Gribaudo, Giorgio; Loregian, Arianna
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
2018 Mercorelli, Beatrice; Palù, Giorgio; Loregian, Arianna
Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein
2018 Mercorelli, Beatrice; Luganini, Anna; Celegato, Marta; Palù, Giorgio; Gribaudo, Giorgio; Loregian, Arianna
A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells
2018 Messa, Lorenzo; Celegato, Marta; Bertagnin, Chiara; Mercorelli, Beatrice; Nannetti, Giulio; Palù, Giorgio; Loregian, Arianna
Drug Repurposing Approach Identifies Inhibitors of the Prototypic Viral Transcription Factor IE2 that Block Human Cytomegalovirus Replication
2016 Mercorelli, Beatrice; Luganini, Anna; Nannetti, Giulio; Tabarrini, Oriana; Palu', Giorgio; Gribaudo, Giorgio; Loregian, Arianna
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling
2016 Trist, Iuni M. L.; Nannetti, Giulio; Tintori, Cristina; Fallacara, Anna Lucia; Deodato, Davide; Mercorelli, Beatrice; Palu', Giorgio; Wijtmans, Maikel; Gospodova, Tzveta; Edink, Ewald; Verheij, Mark; De Esch, Iwan; Viteva, Lilia; Loregian, Arianna; Botta, Maurizio
Legenda icone
- file ad accesso aperto
- file disponibili sulla rete interna
- file disponibili agli utenti autorizzati
- file disponibili solo agli amministratori
- file sotto embargo
- nessun file disponibile