The subunits of the troponin complex-troponin C, troponin T, and troponin I-are responsible for the Ca2+-dependent regulation of contractile activity in heart and skeletal muscle. Distinct troponin T and I isoforms, generated by different genes or by alternative splicing from the same gene, are expressed during cardiac development. Troponin switching affects the Ca2+ sensitivity of the contractile system and may account for the greater resistance to hypoxia and acidosis, and the impaired responsiveness to adrenergic stimulation of the fetal and neonatal heart.
TROPONIN ISOFORM SWITCHING IN THE DEVELOPING HEART AND ITS FUNCTIONAL CONSEQUENCES
SCHIAFFINO, STEFANO;GORZA, LUISA;AUSONI, SIMONETTA
1993
Abstract
The subunits of the troponin complex-troponin C, troponin T, and troponin I-are responsible for the Ca2+-dependent regulation of contractile activity in heart and skeletal muscle. Distinct troponin T and I isoforms, generated by different genes or by alternative splicing from the same gene, are expressed during cardiac development. Troponin switching affects the Ca2+ sensitivity of the contractile system and may account for the greater resistance to hypoxia and acidosis, and the impaired responsiveness to adrenergic stimulation of the fetal and neonatal heart.File in questo prodotto:
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