The expression of NCX genes is controlled by diverse signal transduction pathways. The transcription of the NCX2 gene during the maturation of cerebellar granule neurons is rapidly down-regulated by calcium in a precess that is mediated by calcineurin, whereas that of NCX1 and NCX2 is not affected. The structure of NCX1 gene is not knowns. An unusually large exon, which has been found aòlso in NCX3 gene encodes about two thirds of the full-length NCx1 protein. This large exon (exon 2) encodes a functional exchanger truncated after Val 600.
Transcriptional control of the Na+/ Ca2+ exchanger
GABELLINI, NADIA;
2000
Abstract
The expression of NCX genes is controlled by diverse signal transduction pathways. The transcription of the NCX2 gene during the maturation of cerebellar granule neurons is rapidly down-regulated by calcium in a precess that is mediated by calcineurin, whereas that of NCX1 and NCX2 is not affected. The structure of NCX1 gene is not knowns. An unusually large exon, which has been found aòlso in NCX3 gene encodes about two thirds of the full-length NCx1 protein. This large exon (exon 2) encodes a functional exchanger truncated after Val 600.File in questo prodotto:
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