Certain bacterial species of the genus Clostridium are characterized by their ability to produce extremely potent neurotoxins: tetanus neurotoxin (TeNT) and botulinum neurotoxin (BoNT). TeNT inhibits neurotransmitter release at CNS synapses causing the spastic paralysis of tetanus; BoNT inhibits the release of acethylcholine at peripheral cholinergic nerve terminals causing the flaccid paralysis of botulism. To date, one TeNT and seven (A-G) serologically distinct BoNTs are known (Schiavo et al., 2000).

Neurotoxigenic Clostridia

MONTECUCCO, CESARE;ROSSETTO, ORNELLA;
2005

Abstract

Certain bacterial species of the genus Clostridium are characterized by their ability to produce extremely potent neurotoxins: tetanus neurotoxin (TeNT) and botulinum neurotoxin (BoNT). TeNT inhibits neurotransmitter release at CNS synapses causing the spastic paralysis of tetanus; BoNT inhibits the release of acethylcholine at peripheral cholinergic nerve terminals causing the flaccid paralysis of botulism. To date, one TeNT and seven (A-G) serologically distinct BoNTs are known (Schiavo et al., 2000).
2005
The Prokaryotes: An Evolving Electronic Resource for the Microbiological Community
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/1424497
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