The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chaing length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
DNA-based ligands for Human Cathepsin and medicaments thereof
PALUMBO, MANLIO;GATTO, BARBARA;
2005
Abstract
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chaing length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.File in questo prodotto:
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