Modulation of neurogenic inflammation in osteoarthrosis patients undergoing a combined treatment of mud packs, thermal baths, and acetaminophen: a preliminary study

Osteoarthritis (OA) is the most common joint disease. Certain neuropeptides contribute to both the continuance of symptoms and cartilage damage resulting from disease. Symptomatic drugs are frequentely used for pain control, but dissatisfaction with such an intervention has led many patients to seek for other treatments, one of which is thermal heat from mud packs. The aims of the present study were to investigate a possible interaction between termal treatment and the main neuropeptides involved in OA pathogenesis and to identify any detrimental effect of heat application on OA joints.