In this work we present the labelling procedures of a new somatostatin (sst) analogous with 99mTc and 177Lu using two different chelating agents. The labelled peptide was obtained in both cases in high yield and with high radiochemical purity, showing a good stability in vitro. Finally biodistribution studies confirmed the affinity of the peptide for sst receptors after labelling: both radiolabelled compounds seems to be good candidates to take forward with preclinical studies.
In vitro and in vivo characterization of new SST analogous labelled with 99mTc and 77Lu
ZANGONI, ELENA;MELENDEZ ALAFORT, LAURA;GIRON, MARIA CECILIA;MAZZI, ULDERICO
2010
Abstract
In this work we present the labelling procedures of a new somatostatin (sst) analogous with 99mTc and 177Lu using two different chelating agents. The labelled peptide was obtained in both cases in high yield and with high radiochemical purity, showing a good stability in vitro. Finally biodistribution studies confirmed the affinity of the peptide for sst receptors after labelling: both radiolabelled compounds seems to be good candidates to take forward with preclinical studies.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
