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EnglishIn this work we present the labelling procedures of a new somatostatin (sst) analogous with 99mTc and 177Lu using two different chelating agents. The labelled peptide was obtained in both cases in high yield and with high radiochemical purity, showing a good stability in vitro. Finally biodistribution studies confirmed the affinity of the peptide for sst receptors after labelling: both radiolabelled compounds seems to be good candidates to take forward with preclinical studies.
| Titolo: | In vitro and in vivo characterization of new SST analogous labelled with 99mTc and 77Lu | |
| Autori: | ||
| Data di pubblicazione: | 2010 | |
| Abstract: | In this work we present the labelling procedures of a new somatostatin (sst) analogous with 99mTc and 177Lu using two different chelating agents. The labelled peptide was obtained in both cases in high yield and with high radiochemical purity, showing a good stability in vitro. Finally biodistribution studies confirmed the affinity of the peptide for sst receptors after labelling: both radiolabelled compounds seems to be good candidates to take forward with preclinical studies. | |
| Handle: | http://hdl.handle.net/11577/2421614 | |
| ISBN: | 9788889884140 | |
| Appare nelle tipologie: | 02.01 - Contributo in volume (Capitolo o Saggio) |
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