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EnglishA new alkyl maleimido activated monomethoxypoly(ethylene glycol) (PEG-C18-Mal) for site-directed protein conjugation was synthesised and characterized. As compared to the commercial mPEG-maleimido, PEG-C18-Mal was more efficient in the bioconjugation to 17Cys of rh-G-CSF in guanidinium free buffer and gave more stable bioconjugate. Also, the new bioconjugate displayed high biological activity.
| Titolo: | Effective G-CSF Site Directed PEGylation of Hindered Aminoacids. |
| Autori: | |
| Data di pubblicazione: | 2007 |
| Abstract: | A new alkyl maleimido activated monomethoxypoly(ethylene glycol) (PEG-C18-Mal) for site-directed protein conjugation was synthesised and characterized. As compared to the commercial mPEG-maleimido, PEG-C18-Mal was more efficient in the bioconjugation to 17Cys of rh-G-CSF in guanidinium free buffer and gave more stable bioconjugate. Also, the new bioconjugate displayed high biological activity. |
| Handle: | http://hdl.handle.net/11577/2450263 |
| Appare nelle tipologie: | 04.01 - Contributo in atti di convegno |
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