Benzydamine is an antiinflammatiry drug used both in humans and animals. In man and in laboratory species it is largerly metabolized and two main unconiugated derivatives are described. BZY N-oxide and Nor-BZY, whose formation involves in rats flavin containing monooxigenases and cytochrome P-450 dependent mixed-function oxydases, respectively. The lack of data on BZY metabolism in domestic animals and the possibility that the drug might be used as a marker of different liver enzyme activity were the starting points of this investigation. Liver microsomes were prepared from cattle, swine, horse and laying hens (each = 4) and incubated with BZY at two different pHs (7.4 and 8.5). The analysis of BZY and its metabolites were performed by HPLC. Both the main metabolites of BZY were produced in all species.
Comparative metabolism of Benzydamine in domestic animals
CAPOLONGO, FRANCESCA;MONTESISSA, CLARA
1998
Abstract
Benzydamine is an antiinflammatiry drug used both in humans and animals. In man and in laboratory species it is largerly metabolized and two main unconiugated derivatives are described. BZY N-oxide and Nor-BZY, whose formation involves in rats flavin containing monooxigenases and cytochrome P-450 dependent mixed-function oxydases, respectively. The lack of data on BZY metabolism in domestic animals and the possibility that the drug might be used as a marker of different liver enzyme activity were the starting points of this investigation. Liver microsomes were prepared from cattle, swine, horse and laying hens (each = 4) and incubated with BZY at two different pHs (7.4 and 8.5). The analysis of BZY and its metabolites were performed by HPLC. Both the main metabolites of BZY were produced in all species.Pubblicazioni consigliate
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