The aim of this study was to examine the expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas. STAT3 protein was demonstrated in both the cytoplasm and nuclei of labelled cells. The expression of STAT3 was observed in 87.50% (35/40) of both haemangiomas and haemangiosarcomas and 72.22% (13/18) of haemangiomas and 100% (22/22) haemangiosarcomas. The percentage of positive cells in haemangiomas and haemangiosarcomas was statistically significant difference (P < 0.0001). These preliminary results indicate that STAT3 is overexpressed in malignant tumours.

Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma

PETTERINO, CLAUDIO;ROSSETTI, ENRICA;DRIGO, MICHELE
2006

Abstract

The aim of this study was to examine the expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas. STAT3 protein was demonstrated in both the cytoplasm and nuclei of labelled cells. The expression of STAT3 was observed in 87.50% (35/40) of both haemangiomas and haemangiosarcomas and 72.22% (13/18) of haemangiomas and 100% (22/22) haemangiosarcomas. The percentage of positive cells in haemangiomas and haemangiosarcomas was statistically significant difference (P < 0.0001). These preliminary results indicate that STAT3 is overexpressed in malignant tumours.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2462873
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact