Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the C-alpha-trisubstituted alpha -amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a C-alpha-tetrasubstituted alpha -amino acid (either alpha -aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.
The First Water-Soluble 310-Helical Peptides
FORMAGGIO, FERNANDO;SCRIMIN, PAOLO MARIA;TONIOLO, CLAUDIO
2000
Abstract
Two water-soluble 3(10)-helical peptides are synthesized and fully characterized for the first time. The sequence of these terminally blocked heptamers comprises two residues of the C-alpha-trisubstituted alpha -amino acid 2-amino-3-[1-(1,4,7-triazacyclononyl)]propanoic acid and five residues of a C-alpha-tetrasubstituted alpha -amino acid (either alpha -aminoisobutyric acid or isovaline). Using CD and NMR techniques we were able to show that both heptapeptides are well structured in water, and that the type of conformation adopted is indeed the ternary 3(10)-helix.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
