The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.
Polymer control of ligand display on gold nanoparticles for multimodal switchable targeting
MASTROTTO, FRANCESCA;CALICETI, PAOLO;AMENDOLA, VINCENZO;BERSANI, SARA;MENEGHETTI, MORENO;SALMASO, STEFANO
2011
Abstract
The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.File in questo prodotto:
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