FCE 22176, a stable derivative of a PGI2 analogue, was studied in guinea-pig isolated atria and trachea. The compound was without inotropic or chronotropic effects in spontaneously beating atria and did not alter tracheal tone. By contrast, FCE 22176 competitively antagonized the inotropic effect of PGI2 on atria, and inhibited the PGI2-induced contraction of tracheal chains. Furthermore, in tracheal chains, FCE 22176 was able to antagonize the contractile effect of PGF2 alpha, and to enhance PGE2-induced relaxation. These data support our previous findings that FCE 22176 is a PGI2 antagonist, and provide evidence also for a more complex effect on prostaglandin receptors.

Interaction of FCE 22176, a stable prostacyclin analogue, with different prostaglandins in guinea-pig trachea and atria.

RAGAZZI, EUGENIO;FROLDI, GUGLIELMINA
1990

Abstract

FCE 22176, a stable derivative of a PGI2 analogue, was studied in guinea-pig isolated atria and trachea. The compound was without inotropic or chronotropic effects in spontaneously beating atria and did not alter tracheal tone. By contrast, FCE 22176 competitively antagonized the inotropic effect of PGI2 on atria, and inhibited the PGI2-induced contraction of tracheal chains. Furthermore, in tracheal chains, FCE 22176 was able to antagonize the contractile effect of PGF2 alpha, and to enhance PGE2-induced relaxation. These data support our previous findings that FCE 22176 is a PGI2 antagonist, and provide evidence also for a more complex effect on prostaglandin receptors.
1990
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2481962
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact