A model of the insulin secretion process is presented. The model aims to be a simple one as compared with previous models, i.e. it predicts experimental evidence on insulin secretion under a variety of glucose inputs with a mathematical structure of low complexity. The model predicts in the β-pancreas two linearly connected pools of stored and promptly releasable insulin. Insulin synthesis and release have been modelled as nonlinear glucose-controlled processes. Validation of the model is made by simulation studies both on insulin secretion data as well as on blood insulin concentration data, by aggregating the proposed model to a compartmental model of insulin kinetics.
On a simple model of insulin secretion.
COBELLI, CLAUDIO;
1980
Abstract
A model of the insulin secretion process is presented. The model aims to be a simple one as compared with previous models, i.e. it predicts experimental evidence on insulin secretion under a variety of glucose inputs with a mathematical structure of low complexity. The model predicts in the β-pancreas two linearly connected pools of stored and promptly releasable insulin. Insulin synthesis and release have been modelled as nonlinear glucose-controlled processes. Validation of the model is made by simulation studies both on insulin secretion data as well as on blood insulin concentration data, by aggregating the proposed model to a compartmental model of insulin kinetics.Pubblicazioni consigliate
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