Reaction of the N-carboxyanhydride from C-alpha-methyl D-phenylglycine with either 6-aminopenicillanic acid or 7-amino-3-desacetoxy-cephalosporanic acid furnishes the corresponding ampicillin and cephalexin analogues. Neither the biological activity nor the chemical stability of these new semi-synthetic antibiotics are superior to those of their unmethylated counterparts.
C-alpha-methyl phenylglycine-based semi-synthetic ampicillin and cephalexin analogues
FORMAGGIO, FERNANDO;TONIOLO, CLAUDIO;
1998
Abstract
Reaction of the N-carboxyanhydride from C-alpha-methyl D-phenylglycine with either 6-aminopenicillanic acid or 7-amino-3-desacetoxy-cephalosporanic acid furnishes the corresponding ampicillin and cephalexin analogues. Neither the biological activity nor the chemical stability of these new semi-synthetic antibiotics are superior to those of their unmethylated counterparts.File in questo prodotto:
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