The aggregation propensities of two Ala-based pentapeptides [Py-CH2-CO-(L-Ala)5-OtBu (A5P) and Py-CH2-CO-(L-Ala)3- Aib-L-Ala-OtBu (A3UAP)], both functionalized with a pyrene (Py) aromatic chromophore at the N-terminus, have been investigated in methanol/water solvent mixtures by optical spectroscopies and in dried conditions by atomic force microscopy.
Model Peptide Aggregates: the Role of Aromatic Interactions and Conformational Aspects
FORMAGGIO, FERNANDO;TONIOLO, CLAUDIO;
2011
Abstract
The aggregation propensities of two Ala-based pentapeptides [Py-CH2-CO-(L-Ala)5-OtBu (A5P) and Py-CH2-CO-(L-Ala)3- Aib-L-Ala-OtBu (A3UAP)], both functionalized with a pyrene (Py) aromatic chromophore at the N-terminus, have been investigated in methanol/water solvent mixtures by optical spectroscopies and in dried conditions by atomic force microscopy.File in questo prodotto:
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