In this study we describe novel pH-sensitive PEGylated liposomes for site directed tumor targeting. pH-sensitive liposomes were obtained by including the amphiphilic molecule stearoyl-PEG-(sulfadimethoxine)11 in the liposome bilayer. At pH 6.5, the responsive nanosystem undergoes aggregation and selective association with tumor cells. The liposomes have stealth behavior at physiologic pH. Their responsiveness was found to be affected by the molar ratio of stearoyl-PEG-poly(sulfadimethoxine) assembled with the bilayer.
pH-Sensitive PEGylated Liposomes For Tumour Cell Targeting.
MASTROTTO, FRANCESCA;CALICETI, PAOLO;SALMASO, STEFANO
2011
Abstract
In this study we describe novel pH-sensitive PEGylated liposomes for site directed tumor targeting. pH-sensitive liposomes were obtained by including the amphiphilic molecule stearoyl-PEG-(sulfadimethoxine)11 in the liposome bilayer. At pH 6.5, the responsive nanosystem undergoes aggregation and selective association with tumor cells. The liposomes have stealth behavior at physiologic pH. Their responsiveness was found to be affected by the molar ratio of stearoyl-PEG-poly(sulfadimethoxine) assembled with the bilayer.
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