The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.

Conversion of rat xanthine dehydrogenase to xanthine oxidase during oxidative stress

BINDOLI, ALBERTO;CAVALLINI, LUCIA;RIGOBELLO, MARIA PIA;DI LISA, FABIO
1988

Abstract

The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.
1988
The role of oxygen radicals in cardiovascular diseases
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2524705
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