The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.

Conversion of rat xanthine dehydrogenase to xanthine oxidase during oxidative stress

BINDOLI, ALBERTO;CAVALLINI, LUCIA;RIGOBELLO, MARIA PIA;DI LISA, FABIO
1988

Abstract

The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.
The role of oxygen radicals in cardiovascular diseases
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2524705
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact