The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.
Conversion of rat xanthine dehydrogenase to xanthine oxidase during oxidative stress
BINDOLI, ALBERTO;CAVALLINI, LUCIA;RIGOBELLO, MARIA PIA;DI LISA, FABIO
1988
Abstract
The enzyme “xanthine oxidase” is one of the best characterized sources of superoxide anion and hydrogen peroxide. “in vivo” it mainly acts as a dehydrogenase which, by reducing NAD+, appears to be the physiologic form. Nevertheless under variety of conditions the enzyme can undergo a conversion to an oxidase which delivers the electrons to oxygen to form superoxide and hydrogen peroxide. The transformation xanthine dehydrogenase to xanthine oxidase is irreversible when it is induced by a proteolitic attack or reversible when the SH groups of the enzyme have been oxidized.File in questo prodotto:
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