Abstract Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.

Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging

CREPALDI, GAETANO;Maggi S;PERISSINOTTO, EGLE;SERGI, GIUSEPPE
2011

Abstract

Abstract Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.
Neurobiology ofAging
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2533677
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