Among the large number of new molecules reported as anticancer agents, gold(III)-dithiocarbamato complexes were found to be potentially better than other chemotherapeutics. Our compounds, has been designed to combine the ‘bullet’ character of the metal center with the stabilizing effect of the sulfur chelating ligands. Moreover, the targeting properties of the peptide moiety recognized by PEPTs peptide transporters, grant a marked cell penetrating properties which results in good antitumor activity together with negligible toxicity. Two compounds in particular, dubbed AuD8 and AuD6, have been selected as potential candidates for the development.
Groundbreaking gold(III)-based anticancer agents
FREGONA, DOLORES
2012
Abstract
Among the large number of new molecules reported as anticancer agents, gold(III)-dithiocarbamato complexes were found to be potentially better than other chemotherapeutics. Our compounds, has been designed to combine the ‘bullet’ character of the metal center with the stabilizing effect of the sulfur chelating ligands. Moreover, the targeting properties of the peptide moiety recognized by PEPTs peptide transporters, grant a marked cell penetrating properties which results in good antitumor activity together with negligible toxicity. Two compounds in particular, dubbed AuD8 and AuD6, have been selected as potential candidates for the development.Pubblicazioni consigliate
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