We report the preparation of a “smart” system obtained by decorating gold nanoparticles with pH responsive polymers and folic acid. The gold nanoparticle decoration is aimed at improving site-selectivity in the tumour compartment where the mild acidic conditions trigger the biorecognition of folate receptor overexpressing cancer cells.
Gold nanoparticles with site-triggered biorecognition for cancer targeting.
SALMASO, STEFANO;BRAZZALE, CHIARA;MASTROTTO, FRANCESCA;CALICETI, PAOLO
2013
Abstract
We report the preparation of a “smart” system obtained by decorating gold nanoparticles with pH responsive polymers and folic acid. The gold nanoparticle decoration is aimed at improving site-selectivity in the tumour compartment where the mild acidic conditions trigger the biorecognition of folate receptor overexpressing cancer cells.
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