The objective this study was to estimate genetic parameters for hip (HD) and elbow dysplasia (ED) in Italian Bernese Mountain dogs. Data included screening results provided by two different screen- ing centres of 2051 dogs (1223 females and 828 males) for HD and 1564 dogs (935 females and 629 males) for ED. Screening date ranged from 1995 to 2011 and from 1999 to 2011 for HD and ED, respectively. The outcome variables were: HD score, performed according to the official protocol of the Federation Cynologique Internationale (FCI) and based on a 5-class linear scoring system (from A to E); and ED score, performed according to the International Elbow Working Group (IEWG) protocol and based on a 4-class grading system (from grade 0 to grade III). The pedigree file was provided by the Italian Kennel club (ENCI) and included 5983 dogs. A Bayesian analysis was implemented via Gibbs sam- pling. Effects of sex, year-month of birth, age of the dog at screen- ing, the experience of the x-raying veterinarian and the screening centre were assigned flat priors; those of kennel and animals were given Gaussian prior distributions. Prevalence for HD (i.e. percent- age of hips scored C, D or E) was 15.9%, and prevalence for ED (i.e. percentage of elbows graded I, II or III) was 20.3%. Marginal poste- rior medians and the lower and upper bound of the 95% highest posterior density (HPD95) of heritabilities of HD and ED were 0.22 (0.13-0.33) and 0.16 (0.07-0.30), respectively. The genetic correla- tion between these two traits were 0.53 and the HPD95 did not include zero. These could ensures feasibility of selection pro- grammes aimed to reduce prevalence of skeletal diseases, provided that a regular screening program of Bernese Mountain dogs is per- formed.
Genetic analysis of elbow and hip dysplasia in Italian population of Bernese Mountain dogs
CECCHINATO, ALESSIO;GALLO, LUIGI
2013
Abstract
The objective this study was to estimate genetic parameters for hip (HD) and elbow dysplasia (ED) in Italian Bernese Mountain dogs. Data included screening results provided by two different screen- ing centres of 2051 dogs (1223 females and 828 males) for HD and 1564 dogs (935 females and 629 males) for ED. Screening date ranged from 1995 to 2011 and from 1999 to 2011 for HD and ED, respectively. The outcome variables were: HD score, performed according to the official protocol of the Federation Cynologique Internationale (FCI) and based on a 5-class linear scoring system (from A to E); and ED score, performed according to the International Elbow Working Group (IEWG) protocol and based on a 4-class grading system (from grade 0 to grade III). The pedigree file was provided by the Italian Kennel club (ENCI) and included 5983 dogs. A Bayesian analysis was implemented via Gibbs sam- pling. Effects of sex, year-month of birth, age of the dog at screen- ing, the experience of the x-raying veterinarian and the screening centre were assigned flat priors; those of kennel and animals were given Gaussian prior distributions. Prevalence for HD (i.e. percent- age of hips scored C, D or E) was 15.9%, and prevalence for ED (i.e. percentage of elbows graded I, II or III) was 20.3%. Marginal poste- rior medians and the lower and upper bound of the 95% highest posterior density (HPD95) of heritabilities of HD and ED were 0.22 (0.13-0.33) and 0.16 (0.07-0.30), respectively. The genetic correla- tion between these two traits were 0.53 and the HPD95 did not include zero. These could ensures feasibility of selection pro- grammes aimed to reduce prevalence of skeletal diseases, provided that a regular screening program of Bernese Mountain dogs is per- formed.
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