Melatonin (5-methoxytryptamine) is a natural occurring molecule which exerts physiologic role of circadian sleep-wake cycle in humans. Melatonin is secreted from the pineal gland placed i the center of the brain, far from blood-brain barrier. Thanks to its ascertained safety in humans and low cost, melatonin is widely employed in the market of drugs and nutritional supplements mainly claiming its effectiveness in sleep-wake cycle regularization, anxiolytic and antioxidant activity. Over the last decades, melatonin bioavailability has been investigated in humans and animal models. Literature data pointed out a limited bioavailability of malatonin after oral intake, together withah high variability from subject to subject.
Nanoemulsion technology for sublingual delivery of Melatonin : Characterization and Preliminary Data of absorption
A. Fratter;SEMENZATO, ALESSANDRA;
2013
Abstract
Melatonin (5-methoxytryptamine) is a natural occurring molecule which exerts physiologic role of circadian sleep-wake cycle in humans. Melatonin is secreted from the pineal gland placed i the center of the brain, far from blood-brain barrier. Thanks to its ascertained safety in humans and low cost, melatonin is widely employed in the market of drugs and nutritional supplements mainly claiming its effectiveness in sleep-wake cycle regularization, anxiolytic and antioxidant activity. Over the last decades, melatonin bioavailability has been investigated in humans and animal models. Literature data pointed out a limited bioavailability of malatonin after oral intake, together withah high variability from subject to subject.Pubblicazioni consigliate
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