Positron emission tomography (PET) allows quantitative functional imaging of physiological parameters in terms, for instance, of receptor binding, fractional metabolic uptake, volume of distribution, and blood flow. In fact, the radioactivity concentration measured with PET can be related to the underlying physiological processes using appropriate tracer kinetic modelling techniques.This chapter presents a review of the basic methods for quantitative PET, including the most used compartmental models, as well as the graphical methods of Patlak and Logan, and the single-input/single-output model called spectral analysis. The physiological information can be computed for the time activity curve of an anatomical region of interest (ROI) or for the time activity curve of every voxel, the latter approach resulting in images of parameter estimates called parametric maps.
Physiological Modelling of Positron Emission Tomography Images
BERTOLDO, ALESSANDRA;COBELLI, CLAUDIO
2013
Abstract
Positron emission tomography (PET) allows quantitative functional imaging of physiological parameters in terms, for instance, of receptor binding, fractional metabolic uptake, volume of distribution, and blood flow. In fact, the radioactivity concentration measured with PET can be related to the underlying physiological processes using appropriate tracer kinetic modelling techniques.This chapter presents a review of the basic methods for quantitative PET, including the most used compartmental models, as well as the graphical methods of Patlak and Logan, and the single-input/single-output model called spectral analysis. The physiological information can be computed for the time activity curve of an anatomical region of interest (ROI) or for the time activity curve of every voxel, the latter approach resulting in images of parameter estimates called parametric maps.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
