Cancer metastasis includes tumor cell intravasation, transport and immune evasion within the circulatory system, arrest at a secondary site, extravasation and finally, colonization and growth [1]. However, cancer metastasis remains poorly understood in terms of clinical outcome, pathology and tissue specificity of different tumor types. The predilection of some cancers to target and proliferate in bone is also unclear (Figure 2.1). Less than 1% of cancer cells entering the blood circulation successfully generate metastatic foci [2]. Consequently, there are few successful treatments that directly target metastatic cancer; identifying effective therapeutic targets for this stage of cancer and prognostic factors to identify those patients prone to develop local and distant progressive disease is challenging [2].
Metastatic spread to bone: the role of Chemotherapy.
RUGGIERI, PIETRO
2012
Abstract
Cancer metastasis includes tumor cell intravasation, transport and immune evasion within the circulatory system, arrest at a secondary site, extravasation and finally, colonization and growth [1]. However, cancer metastasis remains poorly understood in terms of clinical outcome, pathology and tissue specificity of different tumor types. The predilection of some cancers to target and proliferate in bone is also unclear (Figure 2.1). Less than 1% of cancer cells entering the blood circulation successfully generate metastatic foci [2]. Consequently, there are few successful treatments that directly target metastatic cancer; identifying effective therapeutic targets for this stage of cancer and prognostic factors to identify those patients prone to develop local and distant progressive disease is challenging [2].Pubblicazioni consigliate
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