Our evidences of Hypoxia reporter response in polg morphants and in embryos treated with OXPHOS complexes inhibitors suggest the existence of cross-talk mechanisms sensing mitochondrial dysfunction and acting on Hypoxia signaling.

Mitochondrial DNA depletion and OXPHOS complex impairment modify Hypoxia signaling pathway activity in zebrafish

MARTORANO, LAURA;TISO, NATASCIA;BUSOLIN, GIORGIA;EK, OLIVIER FREDERIC D;FACCHINELLO, NICOLA;VETTORI, ANDREA;ARGENTON, FRANCESCO
2016

Abstract

Our evidences of Hypoxia reporter response in polg morphants and in embryos treated with OXPHOS complexes inhibitors suggest the existence of cross-talk mechanisms sensing mitochondrial dysfunction and acting on Hypoxia signaling.
ZDM9, The 9th Zebrafish Disease Models Conference
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3208895
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