Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must provide an adequate supply of the anabolic building blocks required to meet a relentless proliferation pressure. This can occur in conditions of inconstant blood perfusion leading to variations in oxygen and nutrient levels. Mitochondria afford the bioenergetic plasticity that allows tumor cells to adapt and thrive in this ever changing and often unfavorable environment. Here we analyse how mitochondria orchestrate the profound metabolic rewiring required for neoplastic growth.

Metabolic plasticity of tumor cell mitochondria

CANNINO, GIUSEPPE
Writing – Original Draft Preparation
;
CISCATO, FRANCESCO
Writing – Original Draft Preparation
;
MASGRAS, IONICA
Writing – Original Draft Preparation
;
SANCHEZ MARTIN, CARLOS
Writing – Original Draft Preparation
;
Andrea Rasola
Writing – Review & Editing
2018

Abstract

Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must provide an adequate supply of the anabolic building blocks required to meet a relentless proliferation pressure. This can occur in conditions of inconstant blood perfusion leading to variations in oxygen and nutrient levels. Mitochondria afford the bioenergetic plasticity that allows tumor cells to adapt and thrive in this ever changing and often unfavorable environment. Here we analyse how mitochondria orchestrate the profound metabolic rewiring required for neoplastic growth.
2018
File in questo prodotto:
File Dimensione Formato  
cannino et al frontonc2018.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Postprint (accepted version)
Licenza: Accesso gratuito
Dimensione 4.6 MB
Formato Adobe PDF
4.6 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3280315
Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 63
social impact