Spatio-temporal relationships between BOLD and MEG signals at rest or during visuospatial attention

The relationship between fMRI and MEG signals between different cortical regions (functional connectivity, FC) has been extensively analyzed in the resting state (De Pasquale et al 2010; Brookes et al 2011; Hipp et al 2012). Much less is known about FC modulations from rest to task states, and how they appear respectively in these two imaging modalities. Previously we have shown task-specific alterations of FC in fMRI during a visuospatial attention task (Spadone et al., PNAS, 2015). Specifically, decrements of resting correlation in visual areas were coupled with increments of correlation between visual and dorsal attention regions. Here, we compared fMRI with band-limited power (BLP) correlation obtained with MEG on the same group of subjects. Aim (i) is to measure frequency specific task-related FC modulations in MEG. Aim (ii) is to compare fMRI- and MEG-FC modulations (task-rest).