Hair analysis is a valuable tool in clinical and forensic toxicology to demonstrate drug exposure when cases of chronic intoxication, use, abuse, or single dose consumption need to be diagnosed in the context of facilitated crimes, withdrawal controls, doping controls, or workplace drug testing, with a large window from weeks to months/years for drug detection. However, scalp hair is exposed to sunlight and/or artificial light for many hours per day; hence, the action of light on hair could alter the content of drugs/illicit drugs and/or metabolites and the xenobiotics can gradually disappear from the hair shaft or be transformed into other compounds having different structure from the parent molecule. Thus, light exposure should be considered as a potential confounder in studies investigating xenobiotics in hair giving rise to reduced drug concentrations or even false negative results. On the other hand, the formation of new photodegradation products could lead to the identification of new markers of abuse useful in forensic evaluations. In order to better understand the role and mechanisms of solar radiation exposure in decreasing hair concentrations of drugs and following our previous photodegradation studies on UVA and UVB induced changes (Drug Test Anal 2014,6,78-84), we have studied the degradation of cocaine (COC) and its metabolite benzoylecgonine (BZE) by irradiating true positive hair samples, containing COC: 0,16-40 ng/mg, and BZE: 0,05-19 ng/mg), in the photostability test chamber (Atlas SUNTEST® CPS+), thus reproducing the complete spectrum of natural solar radiation.

Photolability of Drugs in Hair Atlas SUNTEST® CPS+ and its use for photolability testing of drugs of abuse in human hair

Giorgia Miolo;Luca Menilli;Marianna Tucci;Donata Favretto
2018

Abstract

Hair analysis is a valuable tool in clinical and forensic toxicology to demonstrate drug exposure when cases of chronic intoxication, use, abuse, or single dose consumption need to be diagnosed in the context of facilitated crimes, withdrawal controls, doping controls, or workplace drug testing, with a large window from weeks to months/years for drug detection. However, scalp hair is exposed to sunlight and/or artificial light for many hours per day; hence, the action of light on hair could alter the content of drugs/illicit drugs and/or metabolites and the xenobiotics can gradually disappear from the hair shaft or be transformed into other compounds having different structure from the parent molecule. Thus, light exposure should be considered as a potential confounder in studies investigating xenobiotics in hair giving rise to reduced drug concentrations or even false negative results. On the other hand, the formation of new photodegradation products could lead to the identification of new markers of abuse useful in forensic evaluations. In order to better understand the role and mechanisms of solar radiation exposure in decreasing hair concentrations of drugs and following our previous photodegradation studies on UVA and UVB induced changes (Drug Test Anal 2014,6,78-84), we have studied the degradation of cocaine (COC) and its metabolite benzoylecgonine (BZE) by irradiating true positive hair samples, containing COC: 0,16-40 ng/mg, and BZE: 0,05-19 ng/mg), in the photostability test chamber (Atlas SUNTEST® CPS+), thus reproducing the complete spectrum of natural solar radiation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3299218
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