Model-based design of experiments is exploited to design informative experiments for the identification of heat transfer coefficients in a primary-drying model for the lyophilisation of vaccines. The proposed methodology allows one to design fast and cost-effective experiments for product transfer in different pieces of equipment. The effectiveness of the methodology is tested for different freeze drying units.

Model-based design of experiments to enable fast product transfer across freeze-drying units.

Riccardo De-Luca;Gabriele Bano;Fabrizio Bezzo;Massimiliano Barolo
2019

Abstract

Model-based design of experiments is exploited to design informative experiments for the identification of heat transfer coefficients in a primary-drying model for the lyophilisation of vaccines. The proposed methodology allows one to design fast and cost-effective experiments for product transfer in different pieces of equipment. The effectiveness of the methodology is tested for different freeze drying units.
Proceedings of the 7th European Drying Conference
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3304239
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