The propensity of a helical peptide to undergo thermodirected screw‐sense inversion is connected with its C‐terminal capping moiety. A C‐terminal methyl ester or carboxylic acid actively promotes the onset of a temperature‐driven screw‐sense inversion, whereas a C‐terminal amino alcohol hampers it.

A Temperature-Driven, Reversible, Helical-Handedness Inversion in Peptaibol Analogues Tuned by the C-Terminal Capping Moiety

De Zotti M.
;
Formaggio F.
2019

Abstract

The propensity of a helical peptide to undergo thermodirected screw‐sense inversion is connected with its C‐terminal capping moiety. A C‐terminal methyl ester or carboxylic acid actively promotes the onset of a temperature‐driven screw‐sense inversion, whereas a C‐terminal amino alcohol hampers it.
2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3308077
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