In the last decade, Artificial Pancreas (AP) prototypes, using subcutaneous glucose sensing and subcutaneous insulin delivery, have proved their effectiveness in increasingly complex and realistic clinical trails. At first, they have been extensively tested in experiments involving hospitalized patients (in-patient testing). To ensure the highest level of safety and to limit possible confounding factors, in-patient protocols strictly limited patients’ behavior. Then AP prototypes were tested outside the hospital environment and free of strict protocol prescriptions (out-patient testing) although still under close supervision of the study team. Finally, in the last four years a number of groups showed safety and efficacy of their AP system in real-life conditions. In this chapter, we offer a review of some technological and algorithmic challenges posed by the in-to out-patient transition and report our experience in making this transition possible.

Deployment of modular MPC for type 1 diabetes control: The Italian experience 2008-2016

Del Favero S.;Cobelli C.
2019

Abstract

In the last decade, Artificial Pancreas (AP) prototypes, using subcutaneous glucose sensing and subcutaneous insulin delivery, have proved their effectiveness in increasingly complex and realistic clinical trails. At first, they have been extensively tested in experiments involving hospitalized patients (in-patient testing). To ensure the highest level of safety and to limit possible confounding factors, in-patient protocols strictly limited patients’ behavior. Then AP prototypes were tested outside the hospital environment and free of strict protocol prescriptions (out-patient testing) although still under close supervision of the study team. Finally, in the last four years a number of groups showed safety and efficacy of their AP system in real-life conditions. In this chapter, we offer a review of some technological and algorithmic challenges posed by the in-to out-patient transition and report our experience in making this transition possible.
2019
The Artificial Pancreas: Current Situation and Future Directions
9780128156551
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3342411
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