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EnglishScandium presents different radionuclides with good imaging and therapeutic properties for the development of theranostic radiopharmaceuticals. In particular, 47Sc (t1/2= 3.35 d) has suitable features both for SPECT imaging, thanks to the 159 keV γ-ray emission, and for treatment of small-size tumours, thanks to the intense β− emission (mean β− energy: 162.0 keV). Its efficacy has been demonstrated at preclinical stage, but its low availability has however limited the application of 47Sc-based radiopharmaceuticals to the clinic. Among the different proposed production routes, the natV(p,x)47Sc nuclear reaction is of particular interest, due to the low-cost and easy availability of the target material, as well as the widespread availability of medium-energy cyclotrons. However, the nuclear cross section of this reaction is quite low and small amounts of Sc radioactive contaminants are co-produced. The aim of this work is to evaluate the contribution of Sc-contaminants to the patient radiation dose.
| Titolo: | Dosimetric analysis of the contribution of Radionuclides Coproduced through natV(p,x)47Sc reaction route in Cyclotron Irradiation | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Abstract: | Scandium presents different radionuclides with good imaging and therapeutic properties for the development of theranostic radiopharmaceuticals. In particular, 47Sc (t1/2= 3.35 d) has suitable features both for SPECT imaging, thanks to the 159 keV γ-ray emission, and for treatment of small-size tumours, thanks to the intense β− emission (mean β− energy: 162.0 keV). Its efficacy has been demonstrated at preclinical stage, but its low availability has however limited the application of 47Sc-based radiopharmaceuticals to the clinic. Among the different proposed production routes, the natV(p,x)47Sc nuclear reaction is of particular interest, due to the low-cost and easy availability of the target material, as well as the widespread availability of medium-energy cyclotrons. However, the nuclear cross section of this reaction is quite low and small amounts of Sc radioactive contaminants are co-produced. The aim of this work is to evaluate the contribution of Sc-contaminants to the patient radiation dose. | |
| Handle: | http://hdl.handle.net/11577/3365165 | |
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