Development of transdermal delivery systems for innovative clinical applications of cannabinoids

The use of cannabis for medicinal purposes is deeply rooted in history, dating back to ancient times. While there has been a strong push for legalizing medicinal cannabis and research, conclusive evidence regarding the short- and long-term health effects (harms and benefits) of cannabis use remains elusive because of a high variability when cannabinoids are administered orally or by inhalation. Transdermal delivery of cannabinoids could allow a constant, defined release of these active ingredients. The main goal of this project was to develop innovative pharmaceutical forms in order to ensure a constant release of cannabinoids to the patient. By using a synthesized model molecule, desoxy-CBD, innovative vesicular systems were developed, characterized, and compared with vesicles loaded with cannabis extracts.