Aims of the work were construction and evaluation of recombinant adenoviral vectors for gene therapy of esophageal, hepatocellular and adrenocortical carcinomas in vitro and in vivo. Since adenoviruses have tropism for adrenal gland, human adrenocortical cells were used to assess the toxicity of replication competent adenovirus type 5 and replication incompetent adenoviral vectors. In this regard, the effects of adenoviral infection on adrenocortical gene expression, cell proliferation, cell cycle, cell death and steroidogenesis were investigated.
Construction of Adenoviral vectors for cancer gene therapy and evaluation of toxic effects of adenoviral infection on Adrenocortical cells / Matkovic, Urska. - (2008 Jan 31).
Construction of Adenoviral vectors for cancer gene therapy and evaluation of toxic effects of adenoviral infection on Adrenocortical cells
Matkovic, Urska
2008
Abstract
Aims of the work were construction and evaluation of recombinant adenoviral vectors for gene therapy of esophageal, hepatocellular and adrenocortical carcinomas in vitro and in vivo. Since adenoviruses have tropism for adrenal gland, human adrenocortical cells were used to assess the toxicity of replication competent adenovirus type 5 and replication incompetent adenoviral vectors. In this regard, the effects of adenoviral infection on adrenocortical gene expression, cell proliferation, cell cycle, cell death and steroidogenesis were investigated.File | Dimensione | Formato | |
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