Optical fibers are widely applied to stimulate and monitor neural activity in deep brain regions expressing light-sensitive genetically-encoded sensors and actuators. Recent progress has demonstrated that these probes can be used to perform endoscopic imaging and depth-resolved tissue interrogation. However, label-free sensing of neural events in vivo is still beyond the reach of currently available technologies. To remediate to this shortcoming, we have developed novel methods to fabricate multiple plasmonic bio-sensors on the optically active surface of flat-cleaved and tapered optical fibers.
Towards label-free, implantable neuro-plasmonic probes
Pisano F.;
2021
Abstract
Optical fibers are widely applied to stimulate and monitor neural activity in deep brain regions expressing light-sensitive genetically-encoded sensors and actuators. Recent progress has demonstrated that these probes can be used to perform endoscopic imaging and depth-resolved tissue interrogation. However, label-free sensing of neural events in vivo is still beyond the reach of currently available technologies. To remediate to this shortcoming, we have developed novel methods to fabricate multiple plasmonic bio-sensors on the optically active surface of flat-cleaved and tapered optical fibers.File in questo prodotto:
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