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Alessandra Ricciardi, Elisa Gentilotti, Luigi Coppola, Gaetano Maffongelli, Carlotta Cerva, Vincenzo Malagnino, Alessia Mari, Ambra Di Veroli, Federica Berrilli, Fabiana Apice, Nicola Toschi, David Di Cave, Saverio Giuseppe Parisi, Massimo Andreoni, Loredana Sarmati
Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: A retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients
www.plosone.org
www.plosone.org
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[()2()]TJ
/F7 1 Tf
1.0262 0 Td
(presence.)Tj
-20.7778 -1.2982 Td
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1.9388 0 Td
(hundred)Tj
3.6737 0 Td
(thirty-six)Tj
3.8778 0 Td
(of)Tj
1.0091 0 Td
(the)Tj
1.4684 0 Td
(507)Tj
1.644 0 Td
(respiratory)Tj
4.5921 0 Td
(samples,)Tj
3.6057 0 Td
(98)Tj
1.1679 0 Td
(\(72%\))Tj
2.6078 0 Td
(bronchoalveolar)Tj
6.7238 0 Td
(lavage)Tj
2.6758 0 Td
(flu-)Tj
-36.1811 -1.2983 Td
(ids)Tj
1.3719 0 Td
(or)Tj
1.0998 0 Td
(bronchoaspirates)Tj
7.0809 0 Td
(and)Tj
1.7292 0 Td
(38)Tj
1.1735 0 Td
(\(27.9%\))Tj
3.3052 0 Td
(sputum)Tj
3.2768 0 Td
(samples,)Tj
3.6057 0 Td
(were)Tj
2.1203 0 Td
(positive)Tj
3.3165 0 Td
(for)Tj
/F13 1 Tf
1.3889 0 Td
[()2()]TJ
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1.0262 0 Td
(\(identification)Tj
5.9243 0 Td
(of)Tj
-36.4192 -1.3039 Td
(P)Tj
/F13 1 Tf
[()]TJ
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1.0318 0 Td
(was)Tj
1.7007 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(IF)Tj
1.0885 0 Td
(and)Tj
1.7291 0 Td
(nested-PCR)Tj
5.0003 0 Td
(procedures,)Tj
4.8982 0 Td
(see)Tj
1.4287 0 Td
(below\).)Tj
3.1521 0 Td
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0.9071 0 Td
(total)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(130)Tj
1.6498 0 Td
(patients)Tj
3.3675 0 Td
(tested)Tj
2.5512 0 Td
(posi-)Tj
-35.2684 -1.2983 Td
(tive,)Tj
1.8878 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(medical)Tj
3.3619 0 Td
(records)Tj
3.2031 0 Td
(were)Tj
2.126 0 Td
(reviewed.)Tj
4.0195 0 Td
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1.9389 0 Td
(hundred)Tj
3.6736 0 Td
(sixteen)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(patients)Tj
3.3675 0 Td
(received)Tj
-33.6923 -1.2982 Td
(a)Tj
0.6519 0 Td
(PjP)Tj
1.5931 0 Td
(diagnosis,)Tj
4.1839 0 Td
(and)Tj
1.7348 0 Td
(14)Tj
1.1678 0 Td
(were)Tj
2.126 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(colonized)Tj
4.0819 0 Td
(and)Tj
1.7291 0 Td
(were)Tj
2.126 0 Td
(thus)Tj
1.9332 0 Td
(excluded)Tj
3.7814 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
-31.8328 -1.304 Td
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1.7858 0 Td
(patients')Tj
3.5829 0 Td
(demographic)Tj
5.5049 0 Td
(characteristics,)Tj
6.1285 0 Td
(including)Tj
4.0421 0 Td
(the)Tj
1.4684 0 Td
(inpatient)Tj
3.8267 0 Td
(ward,)Tj
2.4605 0 Td
(underlying)Tj
4.5977 0 Td
(medi-)Tj
-34.5937 -1.2982 Td
(cal)Tj
1.3209 0 Td
(conditions,)Tj
4.6998 0 Td
(PjP)Tj
1.5987 0 Td
(prophylaxis)Tj
4.8869 0 Td
(and)Tj
1.7292 0 Td
(treatment,)Tj
4.3653 0 Td
(radiological)Tj
4.9152 0 Td
(features,)Tj
3.5717 0 Td
(severity)Tj
3.2711 0 Td
(and)Tj
1.7348 0 Td
(outcome)Tj
3.7247 0 Td
(of)Tj
-35.8183 -1.2983 Td
(the)Tj
1.4683 0 Td
(disease,)Tj
3.2428 0 Td
(were)Tj
2.1203 0 Td
(harvested)Tj
4.0422 0 Td
(by)Tj
1.1849 0 Td
(reviewing)Tj
4.1215 0 Td
(the)Tj
1.474 0 Td
(patients')Tj
3.583 0 Td
(medical)Tj
3.3619 0 Td
(records.)Tj
3.4298 0 Td
(To)Tj
1.338 0 Td
(collect)Tj
2.7893 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(data)Tj
-35.7843 -1.2983 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(enrolled)Tj
3.5149 0 Td
(patients,)Tj
3.5943 0 Td
(a)Tj
0.652 0 Td
(database)Tj
3.6397 0 Td
(was)Tj
1.7007 0 Td
(created)Tj
/F13 1 Tf
3.1181 0 Td
[()6()]TJ
1.2019 0 Td
[()6()4()]TJ
/F7 1 Tf
(.)Tj
1.7915 0 Td
(In)Tj
1.1112 0 Td
(a)Tj
0.6519 0 Td
(subgroup)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(50)Tj
1.1736 0 Td
(patients)Tj
3.3675 0 Td
(of)Tj
1.0148 0 Td
(which)Tj
2.6475 0 Td
(a)Tj
-36.68 -1.3039 Td
(sufficient)Tj
3.9117 0 Td
(amount)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(stored)Tj
2.7099 0 Td
(samples)Tj
3.3789 0 Td
(were)Tj
2.126 0 Td
(available,)Tj
3.8891 0 Td
(data)Tj
1.9162 0 Td
(on)Tj
/F13 1 Tf
1.2756 0 Td
[()2()]TJ
/F7 1 Tf
1.0261 0 Td
(genotypes)Tj
4.2179 0 Td
(were)Tj
2.1203 0 Td
(obtained)Tj
3.7361 0 Td
(and)Tj
-34.6788 -1.2982 Td
(considered)Tj
4.5977 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(subsequent)Tj
4.7054 0 Td
(analysis.)Tj
3.549 0 Td
(No)Tj
1.4627 0 Td
(significant)Tj
4.388 0 Td
(differences)Tj
4.5637 0 Td
(in)Tj
1.0375 0 Td
(terms)Tj
2.4945 0 Td
(of)Tj
1.0148 0 Td
(sex,)Tj
1.6951 0 Td
(age,)Tj
1.7631 0 Td
(co-morbid-)Tj
-32.961 -1.2983 Td
(ities,)Tj
2.0636 0 Td
(diseases)Tj
3.3732 0 Td
(severity,)Tj
3.5036 0 Td
(radiological)Tj
4.9152 0 Td
(findings,)Tj
3.719 0 Td
(co-present)Tj
4.4447 0 Td
(lung)Tj
2.007 0 Td
(infections)Tj
4.1499 0 Td
(and)Tj
1.7347 0 Td
(first-line)Tj
3.6397 0 Td
(therapy)Tj
-33.5506 -1.3039 Td
(was)Tj
1.6951 0 Td
(found)Tj
2.6192 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4683 0 Td
(subgroup)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(50)Tj
1.1736 0 Td
(selected)Tj
3.3448 0 Td
(subjects)Tj
3.3789 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(rest)Tj
1.6725 0 Td
(of)Tj
1.0148 0 Td
(population)Tj
4.5921 0 Td
(\(data)Tj
2.2506 0 Td
(not)Tj
-34.9622 -1.2983 Td
(shown\))Tj
1.1962 -1.2982 Td
(All)Tj
1.4003 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patients')Tj
3.583 0 Td
(personal)Tj
3.6283 0 Td
(information)Tj
5.0796 0 Td
(was)Tj
1.6952 0 Td
(treated)Tj
2.999 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(confidential)Tj
5.0003 0 Td
(manner,)Tj
3.5887 0 Td
(and)Tj
1.7291 0 Td
(all)Tj
1.1508 0 Td
(clini-)Tj
-35.223 -1.304 Td
(cal)Tj
1.3209 0 Td
(data)Tj
1.9162 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(anonymously)Tj
5.6296 0 Td
(to)Tj
1.0261 0 Td
(respect)Tj
3.0387 0 Td
(the)Tj
1.4684 0 Td
(patients')Tj
3.5829 0 Td
(privacy.)Tj
3.3676 0 Td
(The)Tj
1.7801 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6952 0 Td
(approved)Tj
-33.0801 -1.2982 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(Tor)Tj
1.7121 0 Td
(Vergata)Tj
3.3392 0 Td
(University)Tj
4.405 0 Td
(Ethical)Tj
2.9877 0 Td
(Committee.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 428.0314 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Definitions)Tj
/F0 1 Tf
0 -1.4976 Td
(PjP)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 393.0519 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(PjP)Tj
1.593 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1792 0 Td
(clinical)Tj
3.0784 0 Td
(signs)Tj
2.2224 0 Td
(of)Tj
1.0147 0 Td
(pneumonia)Tj
4.8132 0 Td
(\(cough,)Tj
3.2372 0 Td
(dyspnoea)Tj
3.9911 0 Td
(and)Tj
1.7292 0 Td
(fever\))Tj
2.5228 0 Td
(and)Tj
1.7291 0 Td
(by)Tj
1.1849 0 Td
(pathologi-)Tj
-33.2218 -1.2982 Td
(cal)Tj
1.3209 0 Td
(changes)Tj
3.4072 0 Td
(of)Tj
1.0148 0 Td
(radiological)Tj
4.9153 0 Td
(examination)Tj
5.2327 0 Td
(\(bilateral)Tj
3.787 0 Td
(reticular)Tj
3.583 0 Td
(or)Tj
1.0998 0 Td
(granular)Tj
3.617 0 Td
(infiltrates,)Tj
4.2463 0 Td
(focal)Tj
2.1203 0 Td
(consoli-)Tj
-34.3443 -1.3039 Td
(dation,)Tj
3.0273 0 Td
(unilateral)Tj
4.0139 0 Td
(infiltrates,)Tj
4.2519 0 Td
(or)Tj
1.0998 0 Td
(nodules\))Tj
3.7021 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(simultaneous)Tj
5.5389 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()2()]TJ
/F7 1 Tf
1.0262 0 Td
(in)Tj
-35.1097 -1.2983 Td
(respiratory)Tj
4.5977 0 Td
(secretions.)Tj
-3.4015 -1.2983 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(respiratory)Tj
4.5977 0 Td
(secretions)Tj
4.2066 0 Td
(of)Tj
1.0148 0 Td
(32)Tj
1.1679 0 Td
(patients,)Tj
/F13 1 Tf
3.5943 0 Td
[()2()]TJ
/F7 1 Tf
1.0261 0 Td
(was)Tj
1.7008 0 Td
(present)Tj
3.1635 0 Td
(with)Tj
1.9955 0 Td
(other)Tj
2.3471 0 Td
(pathogens.)Tj
4.5297 0 Td
(These)Tj
-33.1197 -1.2982 Td
(cases)Tj
2.2223 0 Td
(were)Tj
2.1203 0 Td
(considered)Tj
4.6034 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(the)Tj
1.4684 0 Td
(result)Tj
2.4491 0 Td
(of)Tj
1.0148 0 Td
(concomitant)Tj
5.2951 0 Td
(infections,)Tj
4.3766 0 Td
(and)Tj
1.7292 0 Td
(patients)Tj
3.3675 0 Td
(received)Tj
3.5376 0 Td
(therapy)Tj
-34.3613 -1.3039 Td
(for)Tj
1.3832 0 Td
(both)Tj
2.0637 0 Td
(pathogens.)Tj
4.524 0 Td
(These)Tj
2.5682 0 Td
(cases)Tj
2.2223 0 Td
(were)Tj
2.126 0 Td
(defined)Tj
3.2258 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(text)Tj
1.7064 0 Td
(as)Tj
1.0148 0 Td
(co-present)Tj
4.4447 0 Td
(lung)Tj
2.0069 0 Td
(infections.)Tj
-28.59 -1.2983 Td
(At)Tj
1.2075 0 Td
(admission,)Tj
4.5354 0 Td
(PjP)Tj
1.5931 0 Td
(was)Tj
1.7008 0 Td
(considered)Tj
4.6034 0 Td
(severe)Tj
2.6759 0 Td
(when)Tj
2.4037 0 Td
(the)Tj
1.4684 0 Td
(patient)Tj
3.0104 0 Td
(had)Tj
1.7064 0 Td
(a)Tj
0.652 0 Td
(Pa0)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 482.2299 300.4157 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.0125 302.0598 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
(70)Tj
1.9445 0 Td
(mm)Tj
1.8595 0 Td
(Hg)Tj
1.4513 0 Td
(in)Tj
1.0375 0 Td
(room)Tj
-35.0926 -1.2982 Td
(air)Tj
1.2926 0 Td
(and)Tj
1.7291 0 Td
(required)Tj
3.6397 0 Td
(supplemental)Tj
5.5842 0 Td
(oxygen,)Tj
3.3052 0 Td
(non-invasive)Tj
5.3858 0 Td
(mechanical)Tj
4.7678 0 Td
(ventilation)Tj
4.5127 0 Td
(or)Tj
1.0998 0 Td
(endotracheal)Tj
-31.3169 -1.3039 Td
(intubation.)Tj
1.1962 -1.2983 Td
(A)Tj
0.9071 0 Td
(positive)Tj
3.3165 0 Td
(outcome)Tj
3.7247 0 Td
(of)Tj
1.0148 0 Td
(PjP)Tj
1.5931 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(clinical)Tj
3.0784 0 Td
(improvement)Tj
5.6692 0 Td
(and)Tj
1.7292 0 Td
(survival)Tj
3.3391 0 Td
(after)Tj
2.0352 0 Td
(90)Tj
1.1679 0 Td
(days)Tj
-34.7128 -1.2983 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(pneumonia)Tj
4.8132 0 Td
(diagnosis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 223.0299 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Pj)Tj
1.096 0 Td
(colonization)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 206.022 cm
BT
/F13 1 Tf
1 TL
-0.004 Tc
0 0 Td
[()2()]TJ
/F7 1 Tf
1.0261 0 Td
(colonization,)Tj
5.4085 0 Td
(in)Tj
1.0374 0 Td
(contrast)Tj
3.4639 0 Td
(to)Tj
/F13 1 Tf
1.0262 0 Td
[()2()]TJ
/F7 1 Tf
1.0204 0 Td
(infection,)Tj
4.0195 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(positive)Tj
3.3165 0 Td
(detection)Tj
3.9401 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()2()]TJ
/F7 1 Tf
1.0262 0 Td
(DNA)Tj
2.3754 0 Td
(by)Tj
-36.2492 -1.2982 Td
(PCR)Tj
2.0636 0 Td
(detection)Tj
3.9344 0 Td
(without)Tj
3.3335 0 Td
(signs)Tj
2.2224 0 Td
(or)Tj
1.0998 0 Td
(symptoms)Tj
4.354 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.3301 0 Td
(pneumonia.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 165.9968 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Typical)Tj
3.3496 0 Td
(and)Tj
1.8661 0 Td
(atypical)Tj
3.5623 0 Td
(high-resolution)Tj
6.6851 0 Td
(computed)Tj
4.5638 0 Td
(tomography)Tj
5.4425 0 Td
(\(CT\))Tj
2.2064 0 Td
(PjP)Tj
-27.6758 -1.1669 Td
(radiological)Tj
5.1968 0 Td
(findings)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 134.9858 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(According)Tj
4.439 0 Td
(to)Tj
1.0204 0 Td
(previous)Tj
3.651 0 Td
(published)Tj
4.1273 0 Td
(data)Tj
1.9105 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(],)Tj
2.0806 0 Td
(a)Tj
0.652 0 Td
(fine)Tj
1.7461 0 Td
(reticular)Tj
3.583 0 Td
(interstitial)Tj
4.3029 0 Td
(pulmonary)Tj
4.6488 0 Td
(pattern)Tj
3.1068 0 Td
(with)Tj
-35.2684 -1.2982 Td
(a)Tj
0.6519 0 Td
(prevalent)Tj
3.9401 0 Td
(perihilar)Tj
3.6454 0 Td
(distribution)Tj
4.9662 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(ground)Tj
3.1691 0 Td
(glass)Tj
2.0863 0 Td
(opacities,)Tj
3.9458 0 Td
(small)Tj
2.3244 0 Td
(pneumatocoeles)Tj
6.684 0 Td
(and/)Tj
-35.2627 -1.2983 Td
(or)Tj
1.0941 0 Td
(sub-pleural)Tj
4.7338 0 Td
(blebs)Tj
2.2677 0 Td
(were)Tj
2.1203 0 Td
(considered)Tj
4.6035 0 Td
(typical)Tj
2.8573 0 Td
(PjP)Tj
1.5987 0 Td
(radiological)Tj
4.9153 0 Td
(findings.)Tj
3.719 0 Td
(Dense)Tj
2.7099 0 Td
(lobar)Tj
2.2847 0 Td
(consolida-)Tj
-32.9043 -1.3039 Td
(tion,)Tj
2.0636 0 Td
(nodules,)Tj
3.5886 0 Td
(miliary)Tj
3.0784 0 Td
(opacities,)Tj
3.9458 0 Td
(and)Tj
1.7291 0 Td
(pleural)Tj
2.9877 0 Td
(effusions)Tj
3.7928 0 Td
(are)Tj
1.4456 0 Td
(uncommon)Tj
4.9209 0 Td
(radiological)Tj
4.9209 0 Td
(aspects)Tj
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