RUZZENE, MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 8.987
EU - Europa 830
AS - Asia 663
SA - Sud America 8
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 2
Totale 10.496
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Nazione #
US - Stati Uniti d'America 8.980
CN - Cina 532
FI - Finlandia 201
DE - Germania 159
IT - Italia 145
SE - Svezia 128
VN - Vietnam 102
UA - Ucraina 77
GB - Regno Unito 70
IN - India 23
IE - Irlanda 15
RO - Romania 8
BR - Brasile 7
CA - Canada 7
FR - Francia 7
NL - Olanda 7
AU - Australia 5
RU - Federazione Russa 5
ES - Italia 3
AT - Austria 2
EU - Europa 2
HR - Croazia 2
JP - Giappone 2
AR - Argentina 1
BE - Belgio 1
KR - Corea 1
NZ - Nuova Zelanda 1
PH - Filippine 1
SG - Singapore 1
TR - Turchia 1
Totale 10.496
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Città #
Fairfield 1.481
Woodbridge 1.125
Houston 872
Chandler 748
Ann Arbor 747
Ashburn 634
Wilmington 580
Seattle 537
Cambridge 512
Jacksonville 393
Princeton 192
Beijing 138
San Diego 134
Des Moines 112
Dong Ket 102
Helsinki 91
Nanjing 82
Padova 79
Medford 71
Boardman 63
Roxbury 41
Shenyang 40
Guangzhou 30
Hebei 30
Jinan 23
Nanchang 23
Jiaxing 20
Changsha 18
Dearborn 18
Dublin 15
New York 14
Norwalk 13
Hefei 12
Tianjin 12
Falls Church 11
London 9
Los Angeles 8
Chicago 7
Hangzhou 7
Pune 7
Redwood City 7
Kunming 6
Borås 5
Haikou 5
Lanzhou 5
Ogden 5
Rockville 5
Shanghai 5
São Paulo 5
Taizhou 5
Zhengzhou 5
Auburn Hills 4
Fuzhou 4
Hounslow 4
Munich 4
Nürnberg 4
Cagliari 3
Detroit 3
Dundee 3
Indiana 3
Islington 3
Kharkiv 3
Lappeenranta 3
Paris 3
Perugia 3
Taiyuan 3
Wuhan 3
Acton 2
Belluno 2
Cleveland 2
Core 2
Edinburgh 2
Frankfurt am Main 2
Gubbio 2
Kilburn 2
Melbourne 2
New Bedfont 2
Ningbo 2
Orta di Atella 2
San Francisco 2
Sesto San Giovanni 2
Sydney 2
Tokyo 2
Toronto 2
Washington 2
Xian 2
Amsterdam 1
Arezzo 1
Baotou 1
Berlin 1
Bolzano 1
Borgonovo Val Tidone 1
Boston 1
Boydton 1
Bozzolo 1
Bridgeport 1
Brisbane 1
Cardiff 1
Chengdu 1
Davao City 1
Totale 9.214
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Nome #
PreS1 peptide-functionalized gold nanostructures with SERRS tags for efficient liver cancer cell targeting 172
A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia 161
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours 160
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA) 151
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 149
Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells 145
Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt/PKB subfamily. 143
Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB 141
Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity 139
Protein kinase CK2 phosphorylates and upregulates Akt/PKB 139
Functional Protein Network Activation Mapping Reveals New Potential Molecular Drug Targets for Poor Prognosis Pediatric BCP-ALL 135
Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB 134
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2 127
Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases 127
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study 124
Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential 117
Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells. Biochemical evidence and therapeutic perspectives 117
Site specificity of p72syk protein tyrosine kinase. Efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family 116
Salicylic acid activates nitric oxide synthesis in Arabidopsis 116
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors 114
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes. 113
Bovine prion protein as a modulator of protein kinase CK2 111
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain 109
Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects 109
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole 108
Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides. 106
405 HCV NS5A phosphorylation by CK2 is genotype dependent 105
Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). 105
Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin 105
A comparative study of the phosphotyrosyl phosphatase specificity of PP2A and PTP-1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn 104
The selectivity of inhibitors of protein kinase CK2: an update 103
Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency 103
Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B) 102
Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity 102
Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity 102
Development and exploitation of CK2 inhibitors 101
Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin 101
Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. 99
Phosphorylation, Signaling, and Cancer: Targets and Targeting 99
The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process. 99
Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A 98
Role of protein kinase CK2 in antitumor drug resistance 98
Role of protein kinase CK2 in the retinoic acid-induced differentiation of acute promyelocytic leukemia cells. 96
Addiction to protein kinase CK2: A common denominator of diverse cancer cells? 95
Specific stimulation of c-Fgr kinase by tyrosine-phosphorylated (poly)peptides--possible implication in the sequential mode of protein phosphorylation. 95
Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process. 95
A procedure allowing measurement of cytosolic Ca2+ in rat platelets. Inhibition of a plasma lipoprotein on fura 2-AM loading. 95
How do protein kinases recognize their substrates? 94
Assessment of CK2 Constitutive Activity in Cancer Cells 94
Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene 93
The antioxidant butylated hydroxytoluene stimulates platelet protein kinase C and inhibits subsequent protein phosphorylation induced by thrombin. 93
The spleen protein tyrosine kinase TPK-IIB is highly similar to the catalytic domain of p72syk 93
Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level. 91
Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside. 90
Psoralen—fatty acid cycloadducts activate protein kinase C (PKC) in human platelets 90
Casein kinase: the triple meaning of a misnomer. 89
CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes 88
Effects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy 88
Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions. 87
Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells 86
Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis 86
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response 85
Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells 84
The protein kinase CK2 contributes to the protumorigenic properties of cholangiocarcinoma cells 84
Phosphorylation of p23-1 cochaperone by protein kinase CK2 affects root development in Arabidopsis 84
Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1) - Implication of protein kinase CK2 83
Platelet responses promoted by the activation of protein kinase C or the increase of cytosolic Ca2+ are potentiated by adrenaline. Effects of cAMP and staurosporine. 83
Multiple myeloma cells survival and proliferation rely on high levels and activity of the serine-threonine kinase CK2. 80
Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein. 78
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2 78
Selectivity of 4,5,6,7-tetrabromo-benzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase-2") 77
Protein kinase CK2 accumulation in "oncophilic" cells: causes and effects 75
Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation 75
Multiple myeloma cell survival relies on high activity of protein kinase CK2 75
Addiction of cancer cells to CK2: survival at all costs or Achilles heel? 74
A novel class of selective CK2 inhibitors targeting its open hinge conformation 74
Targeting protein kinase CK2: Evaluating CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice 71
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells 71
Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells 71
Effects of calcium chelators, divalent cations and sulfhydryl reagents on calcium uptake and motility of bovine spermatozoa. 70
Cyclic GMP and nitroprusside inhibit the activation of human platelets by fluoroaluminate. 69
Multiple myeloma cells survival and proliferation rely on high levels and activity of the serine-threonine kinase CK2. 69
Therapeutic targeting of CK2 in acute and chronic leukemias 67
Isolation from spleen of a 57 kDa protein substrate of the tyrosine kinase Lyn: identification as a protein disulphide isomerase related protein and localisation of the phosphorylation sites 66
Cross-talk between the CK2 and AKT signaling pathways in cancer 66
Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival 66
Protein kinase CK2 inhibition as a pharmacological strategy 66
SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases. 65
Hematopietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2. 63
Sequence specificity of C-terminal Src kinase (CSK). A comparison with Src-related kinases c-Fgr and Lyn 63
The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis 62
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain 62
Lamin A Ser404 Is a Nuclear Target of Akt Phosphorylation in C2C12 Cells 62
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2 ('casein kinase-2) 60
Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor 59
Purification and characterization of two casein kinases from ejaculated bovine spermatozoa. 59
Src homology-2 domain protect phosphotyrosil residues against enzymatic dephosphorylation 58
The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin. 57
Aberrant Signalling by Protein Kinase CK2 in Imatinib-resistant Chronic Myeloid Laeukemia Cells 56
ROLE OF PROTEIN KINASE CK2 IN THE SURVIVAL AND CHEMORESISTANCE OF ACUTE MYELOID LEUKEMIA CELLS. 56
Totale 9.470
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Categoria #
all - tutte 35.842
article - articoli 33.489
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 856
Totale 70.187
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019686 0 0 0 0 0 0 0 0 0 0 353 333
2019/20202.513 313 73 59 208 268 193 271 293 293 297 154 91
2020/20211.620 95 89 62 115 96 117 114 139 262 155 185 191
2021/20221.822 39 193 303 141 74 80 84 222 68 36 239 343
2022/20231.412 261 178 29 201 203 224 0 80 127 13 69 27
2023/2024500 54 106 96 38 59 43 35 30 17 19 3 0
Totale 10.601