DI SPIEZIO, ALESSANDRO
DI SPIEZIO, ALESSANDRO
Dipartimento di Scienze Biomediche - DSB
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis
2021 Di Spiezio, A.; Marques, A. R. A.; Schmidt, L.; Thießen, N.; Gallwitz, L.; Fogh, J.; Bartsch, U.; Saftig, P.
Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease
2022 Gallwitz, L.; Schmidt, L.; Marques, A. R. A.; Tholey, A.; Cassidy, L.; Ulku, I.; Multhaup, G.; Di Spiezio, A.; Saftig, P.
Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
2016 Storck, S. E.; Meister, S.; Nahrath, J.; Meissner, J. N.; Schubert, N.; Di Spiezio, A.; Baches, S.; Vandenbroucke, R. E.; Bouter, Y.; Prikulis, I.; Korth, C.; Weggen, S.; Heimann, A.; Schwaninger, M.; Bayer, T. A.; Pietrzik, C. U.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
2020 Marques, A. R. A.; Di Spiezio, A.; Thiessen, N.; Schmidt, L.; Grotzinger, J.; Lullmann-Rauch, R.; Damme, M.; Storck, S. E.; Pietrzik, C. U.; Fogh, J.; Bar, J.; Mikhaylova, M.; Glatzel, M.; Bassal, M.; Bartsch, U.; Saftig, P.
Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation
2016 Imperatore, Roberta; Palomba, Letizia; Morello, Giovanna; Spiezio, Alessandro Di; Piscitelli, Fabiana; Marzo, Vincenzo Di; Cristino, Luigia
Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice
2022 Liu, J.; Bassal, M.; Schlichting, S.; Braren, I.; Di Spiezio, A.; Saftig, P.; Bartsch, U.
Ion Channels and Ionotropic Receptors in Astrocytes: Physiological Functions and Alterations in Alzheimer’s Disease and Glioblastoma
2023 Lia, Annamaria; Di Spiezio, Alessandro; Vitalini, Lorenzo; Tore, Manuela; Puja, Giulia; Losi, Gabriele
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 Pedram, K.; Laqtom, N. N.; Shon, D. J.; Di Spiezio, A.; Riley, N. M.; Saftig, P.; Abu-Remaileh, M.; Bertozzi, C. R.
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
2023 Ulku, I.; Liebsch, F.; Akerman, S. C.; Schulz, J. F.; Kulic, L.; Hock, C.; Pietrzik, C.; Di Spiezio, A.; Thinakaran, G.; Saftig, P.; Multhaup, G.
Nesfatin-1 decreases the motivational and rewarding value of food
2020 Dore, R.; Krotenko, R.; Reising, J. P.; Murru, L.; Sundaram, S. M.; Di Spiezio, A.; Muller-Fielitz, H.; Schwaninger, M.; Johren, O.; Mittag, J.; Passafaro, M.; Shanabrough, M.; Horvath, T. L.; Schulz, C.; Lehnert, H.
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
2022 Prieto Huarcaya, S.; Drobny, A.; Marques, A. R. A.; Di Spiezio, A.; Dobert, J. P.; Balta, D.; Werner, C.; Rizo, T.; Gallwitz, L.; Bub, S.; Stojkovska, I.; Belur, N. R.; Fogh, J.; Mazzulli, J. R.; Xiang, W.; Fulzele, A.; Dejung, M.; Sauer, M.; Winner, B.; Rose-John, S.; Arnold, P.; Saftig, P.; Zunke, F.
The LepR-mediated leptin transport across brain barriers controls food reward
2018 Di Spiezio, A.; Sandin, E. S.; Dore, R.; Muller-Fielitz, H.; Storck, S. E.; Bernau, M.; Mier, W.; Oster, H.; Johren, O.; Pietrzik, C. U.; Lehnert, H.; Schwaninger, M.
Two decades of astrocytes in neurovascular coupling
2023 Lia, Annamaria; Di Spiezio, Alessandro; Speggiorin, Michele; Zonta, Micaela