The hydrocarboalkoxylation of N-vinylphthalimide catalyzed by palladium tertiary phosphine complexes occurs with high selectivity towards the linear isomer when the alcohol is used also as the solvent but towards the branched isomer in the presence of an additional solvent. When triphenylphosphine is employed as the ligand, the yield and the regioselectivity towards the branched isomer increase with increasing pco or decreasing concentration of the phosphine. Reaction in the presence of molecular hydrogen leads to higher yields, with minor changes in regioselectivity. High regioselectivities towards either the linear or the branched isomer are observed also in the presence of chiral di- or mono-phosphines, but the degree of asymmetric induction is very low.
Hydrocarboalkoxylation of N-vinylphtalimide catalyzed by palladium complexes
CAVINATO, GIANNI;
1982
Abstract
The hydrocarboalkoxylation of N-vinylphthalimide catalyzed by palladium tertiary phosphine complexes occurs with high selectivity towards the linear isomer when the alcohol is used also as the solvent but towards the branched isomer in the presence of an additional solvent. When triphenylphosphine is employed as the ligand, the yield and the regioselectivity towards the branched isomer increase with increasing pco or decreasing concentration of the phosphine. Reaction in the presence of molecular hydrogen leads to higher yields, with minor changes in regioselectivity. High regioselectivities towards either the linear or the branched isomer are observed also in the presence of chiral di- or mono-phosphines, but the degree of asymmetric induction is very low.Pubblicazioni consigliate
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