In a family affected by arrhythmogenic right ventricular cardiomyopathy (ARVC) the familial occurrence was investigated. All 14 members of two generations were investigated carefully, and only 2 (father and one son) members were affected. Both subjects had a massive form of the disease with relevant ventricular arrhythmias. Apart from the limitations of having investigated few subjects, this behavior suggests a genetic mutation appearing in the father and transmitted via an autosomal dominant trait. Copyright © 1992 Wiley Periodicals, Inc.
A CASUAL SPONTANEOUS MUTATION AS POSSIBLE CAUSE OF THE FAMILIAL FORM OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA)
NAVA, ANDREA;THIENE, GAETANO
1992
Abstract
In a family affected by arrhythmogenic right ventricular cardiomyopathy (ARVC) the familial occurrence was investigated. All 14 members of two generations were investigated carefully, and only 2 (father and one son) members were affected. Both subjects had a massive form of the disease with relevant ventricular arrhythmias. Apart from the limitations of having investigated few subjects, this behavior suggests a genetic mutation appearing in the father and transmitted via an autosomal dominant trait. Copyright © 1992 Wiley Periodicals, Inc.
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