The amino acid compositions of insoluble collagen and elastin purified from skin biopsies of normal subjects and scleroderma patients were conlpared. Collagen from dermis-subcutaneous tissue from the patients shows a significant increase of 3-OH proline and a slight increase in 4-OH proline and OH-lysine. The greater hydroxylation in collagen of scleroderma tissue can be tentatively explained by the higher levels of hydroxylating enzymes in a tissue with increased collagen synthesis. © 1974 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Collagen and elastin in scleroderma
PESERICO STECCHINI NEGRI DE SALVI, ANDREA;
1974
Abstract
The amino acid compositions of insoluble collagen and elastin purified from skin biopsies of normal subjects and scleroderma patients were conlpared. Collagen from dermis-subcutaneous tissue from the patients shows a significant increase of 3-OH proline and a slight increase in 4-OH proline and OH-lysine. The greater hydroxylation in collagen of scleroderma tissue can be tentatively explained by the higher levels of hydroxylating enzymes in a tissue with increased collagen synthesis. © 1974 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
