Samples of normal human dermis of different ages are reduced with tritiated sodium borohydride and changes of major reducible cross-links are compared as a function of chronological age. While lysinonorleucine practically remains constant, reduced desmosine changes slightly, hydroxylysinonorleucine and dihydroxylysinonorleucine display a marked decrease with age. An unknown compound is shown to increase with aging. The data suggest a correlation between the change of aldimine cross-links and the structural and/or biochemical changes occurring with increase in age.
Age-related changes in the reducible cross-links of human dermis collagen
PESERICO STECCHINI NEGRI DE SALVI, ANDREA
1977
Abstract
Samples of normal human dermis of different ages are reduced with tritiated sodium borohydride and changes of major reducible cross-links are compared as a function of chronological age. While lysinonorleucine practically remains constant, reduced desmosine changes slightly, hydroxylysinonorleucine and dihydroxylysinonorleucine display a marked decrease with age. An unknown compound is shown to increase with aging. The data suggest a correlation between the change of aldimine cross-links and the structural and/or biochemical changes occurring with increase in age.
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