Protecting osmolytes play a crucial role in preventing protein denaturation in harsh environmental conditions of living organisms. Experimental evidence is provided for a mechanism of protein-fold stabilization by these molecules that is in accord with the hypothesis of a backbone-based osmophobic effect. (In picture: ΔG=free energy, [O]=osmolyte concentration, χ=unfolding reaction coordinate.)
Single-molecule-level evidence for the osmophobic effect.
TESSARI, ISABELLA;BUBACCO, LUIGI;
2011
Abstract
Protecting osmolytes play a crucial role in preventing protein denaturation in harsh environmental conditions of living organisms. Experimental evidence is provided for a mechanism of protein-fold stabilization by these molecules that is in accord with the hypothesis of a backbone-based osmophobic effect. (In picture: ΔG=free energy, [O]=osmolyte concentration, χ=unfolding reaction coordinate.)File in questo prodotto:
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