DNA adduct formation has been studied in mussel by using a mesocosm system and 13 day exposure period. Results indicate that B[a]P in feed is bioavailable for the organisms: for the dose applied, its accumulation and biotransformation in mussel resulted in the DNA binding of B[a]P metabolites. Differences in uptake and biotransformation abilities among tissues likely explain the different levels of B[a]P-DNA recorded in digestive gland compared to gills. Data obtained during depuration demonstrate the musseI ability to recover from B[a]P exposure in term of tissue dose and DNA damage. Because mussels are chronically exposed to pollutants in the marine environment, DNA adduct measurement cab be used as a cumulative index of current and recent exposure to genotoxin compounds.
Relationship between kinetics of benzo[a]pyrene bioaccumulation and DNA binding in the mussel Mytilus galloprovincialis.
VENIER, PAOLA;
1999
Abstract
DNA adduct formation has been studied in mussel by using a mesocosm system and 13 day exposure period. Results indicate that B[a]P in feed is bioavailable for the organisms: for the dose applied, its accumulation and biotransformation in mussel resulted in the DNA binding of B[a]P metabolites. Differences in uptake and biotransformation abilities among tissues likely explain the different levels of B[a]P-DNA recorded in digestive gland compared to gills. Data obtained during depuration demonstrate the musseI ability to recover from B[a]P exposure in term of tissue dose and DNA damage. Because mussels are chronically exposed to pollutants in the marine environment, DNA adduct measurement cab be used as a cumulative index of current and recent exposure to genotoxin compounds.Pubblicazioni consigliate
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