Biomimetic polymer nanofibers of poly(ε-caprolactone) and poly(L-lactide–caprolactone) copolymer were prepared by electrospinning. Modifications of the polymer nanofibers aimed at improving their biomimetic properties were performed by two different routes: (1) immobilization of an adhesion peptide, which mimicked the adhesion sequence of the extracellular matrix protein fibronectin, on the polymer surface and (2) incorporation of self-complementary oligopeptides, which showed alternated hydrophilic and hydrophobic side chain groups and was capable of generating extended ordered structures by self-assembling, into the polymer nanofibers. The structure of the polymer/peptide nanofibers was investigated by X-ray photoelectron and Fourier transform infrared spectroscopies.

Biomimetic Peptide-Enriched Electrospun Polymers: A Photoelectron and Infrared Spectroscopy Study

GHEZZO, FRANCESCA;DANESIN, ROBERTA;MODESTI, MICHELE;DETTIN, MONICA
2011

Abstract

Biomimetic polymer nanofibers of poly(ε-caprolactone) and poly(L-lactide–caprolactone) copolymer were prepared by electrospinning. Modifications of the polymer nanofibers aimed at improving their biomimetic properties were performed by two different routes: (1) immobilization of an adhesion peptide, which mimicked the adhesion sequence of the extracellular matrix protein fibronectin, on the polymer surface and (2) incorporation of self-complementary oligopeptides, which showed alternated hydrophilic and hydrophobic side chain groups and was capable of generating extended ordered structures by self-assembling, into the polymer nanofibers. The structure of the polymer/peptide nanofibers was investigated by X-ray photoelectron and Fourier transform infrared spectroscopies.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/127285
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