1 Biochemical changes in male, Wistar rats, treated with different doses of 1,2-dichloropropane (50-500 mg kg-1 body weight), were investigated at the end of a 4-week treatment and after a 4-week recovery period. 2 The behaviour of Phase I and Phase I.I. metabolic steps and of the angiotensin converting enzyme activity of the renal proximal tubule brush border were determined. 3 Phase I.I. is more affected by the solvent than Phase I metabolism, and liver metabolism is more affected than the kidney. 4 Angiotensin converting enzyme activity from the proximal tubule brush border appears to be the most sensitive parameter of kidney involvement during treatment. 5 After a 4-week recovery period all the metabolic indices together with angiotensin converting enzyme activity have returned to normal. Only liver reduced glutathione content shows a slight, but significant, increase for the highest dose (500 mg kg −1 body weight). 6 The results show that the biochemical changes induced in liver and kidney by 1,2-dichloropropane are reversible. © 1991, Sage Publications. All rights reserved.

Recovery of Biochemical Changes Induced by 1, 2-Dichloro propane in Rat Liver and Kidney

TREVISAN, ANDREA;MASO, STEFANO
1991

Abstract

1 Biochemical changes in male, Wistar rats, treated with different doses of 1,2-dichloropropane (50-500 mg kg-1 body weight), were investigated at the end of a 4-week treatment and after a 4-week recovery period. 2 The behaviour of Phase I and Phase I.I. metabolic steps and of the angiotensin converting enzyme activity of the renal proximal tubule brush border were determined. 3 Phase I.I. is more affected by the solvent than Phase I metabolism, and liver metabolism is more affected than the kidney. 4 Angiotensin converting enzyme activity from the proximal tubule brush border appears to be the most sensitive parameter of kidney involvement during treatment. 5 After a 4-week recovery period all the metabolic indices together with angiotensin converting enzyme activity have returned to normal. Only liver reduced glutathione content shows a slight, but significant, increase for the highest dose (500 mg kg −1 body weight). 6 The results show that the biochemical changes induced in liver and kidney by 1,2-dichloropropane are reversible. © 1991, Sage Publications. All rights reserved.
File in questo prodotto:
File Dimensione Formato  
HET, 10 241-244 1991.pdf

accesso aperto

Tipologia: Published (publisher's version)
Licenza: Creative commons
Dimensione 259.89 kB
Formato Adobe PDF
259.89 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/129986
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact