Blood pressure and metabolic phenotypes in relation to the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms in a White population

Previous studies of cases and controls or selected patients demonstrated association of the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms with blood pressure, measures of obesity, and/or serum lipids. In multivariate-adjusted analyses of 1881 subjects randomly recruited froma White population, ADRB1 ArgArg homozygotes, compared with Gly allele carriers, had higher diastolic blood pressure (79.4 vs 78.4mmHg; P¼0.012), and higher serum high-density lipoprotein (HDL) cholesterol (1.33 vs 1.29mmoll1; P¼0.020), whereas none of the other cardiovascular or metabolic phenotypes reached significance in relation to the two polymorphisms. Our family-based design excluded population stratification as a possible explanation for the significant association of the ADRB1 Arg389Gly polymorphism with blood pressure and HDL cholesterol.