An experimental, rat model, of limb replantation was developed to evaluate and compare the efficacy of SOD and mPEG-SOD (native and modified with polyethylene glycole superoxide dismutase) or PAcM-SOD (polyacriloilmorpholine superoxide dismutase) in preventing ischemia- reperfusion damage. In particular, the current research focused on the technical procedure employed for the study of the newly activated motor end-plates after ischemia/reperfusion injury. The experiment was carried out on CO Wistar rats, randomly divided into four groups, submitted to 4 hours and 30 minutes of ischemia of the left hindlimb, followed by reperfusion. Results showed a better limb survival in the mPEG-SOD group (87%) in comparison to other three groups (p<0.05).
Prevention of muscle and nerve damage after a prolonged ischemia/reperfusion syndrome: An experimental animal model
CALICETI, PAOLO
2001
Abstract
An experimental, rat model, of limb replantation was developed to evaluate and compare the efficacy of SOD and mPEG-SOD (native and modified with polyethylene glycole superoxide dismutase) or PAcM-SOD (polyacriloilmorpholine superoxide dismutase) in preventing ischemia- reperfusion damage. In particular, the current research focused on the technical procedure employed for the study of the newly activated motor end-plates after ischemia/reperfusion injury. The experiment was carried out on CO Wistar rats, randomly divided into four groups, submitted to 4 hours and 30 minutes of ischemia of the left hindlimb, followed by reperfusion. Results showed a better limb survival in the mPEG-SOD group (87%) in comparison to other three groups (p<0.05).
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
